The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking

The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Cancers
Volume: 13
Number: 7
Page Range: p. 1724
Date: 2021
Divisions: Lipid Cell Biology
Vascular Biology
Depositing User: General Admin
Identification Number: 10.3390/cancers13071724
ISSN: 2072-6694
Date Deposited: 10 Jun 2021 05:53

The effectiveness of immunotherapy against solid tumours is dependent on the appropriate leucocyte subsets trafficking and accumulating in the tumour microenvironment (TME) with recruitment occurring at the endothelium. Such recruitment involves interactions between the leucocytes and the endothelial cells (ECs) of the vessel and occurs through a series of steps including leucocyte capture, their rolling, adhesion, and intraluminal crawling, and finally leucocyte transendothelial migration across the endothelium. The tumour vasculature can curb the trafficking of leucocytes through influencing each step of the leucocyte recruitment process, ultimately producing an immunoresistant microenvironment. Modulation of the tumour vasculature by strategies such as vascular normalisation have proven to be efficient in facilitating leucocyte trafficking into tumours and enhancing immunotherapy. In this review, we discuss the underlying mechanisms of abnormal tumour vasculature and its impact on leucocyte trafficking, and potential strategies for overcoming the tumour vascular abnormalities to boost immunotherapy via increasing leucocyte recruitment.

Zhao, Yang
Ting, Ka Ka
Coleman, Paul
Qi, Yanfei
Chen, Jinbiao
Vadas, Mathew
Gamble, Jennifer
Last Modified: 10 Jun 2021 05:53

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