MicroRNAs in toxic acute kidney injury: Systematic scoping review of the current status

MicroRNAs in toxic acute kidney injury: Systematic scoping review of the current status.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/prp2.695
Journal or Publication Title: Pharmacology Research & Perspectives
Volume: 9
Number: 2
Date: 2021
Divisions: Alcoholic Liver Disease
Depositing User: General Admin
Identification Number: 10.1002/prp2.695
ISSN: 2052-1707
Date Deposited: 10 Jun 2021 05:49

Acute kidney injury induced by nephrotoxic agents is common, increasing in incidence and associated with considerable morbidity and mortality in developing countries. MicroRNAs are stable biomarkers that can be detected in extracellular fluids. This systematic scoping review aims to describe published research on urinary and circulating microRNAs in toxic acute kidney injury in both animal and human studies. We conducted a literature search, using EMBASE and Medline, for articles on urinary and circulating microRNA in nephrotoxic injuries to February 2020. A total of 21 publications studied acute kidney injury from 12 different toxic agents. Cisplatin was the most common nephrotoxic agent (n = 10), followed by antibiotics (n = 4). There were no randomized controlled trials. An increase in urinary miR-218 predicted acute kidney injury in six different studies, suggesting it is a promising biomarker for nephrotoxin-induced acute kidney injury. There were many factors that prevented a more comprehensive synthesis of microRNA performance including highly variable models, no consistent protocols for RNA isolation, cDNA synthesis and PCR amplification, and variability in normalization methods using reference controls. In conclusion, while microRNAs are promising biomarkers to study nephrotoxic acute kidney injury, the replication of most positive findings is not assessable due to deficient reporting of negative outcomes. A very narrow range of poisons have been studied, and more human data are required. In particular, further studies are needed on the most important causes of nephrotoxic injury, such as pesticides, chemicals, snake envenoming, and medicines other than aminoglycosides and cisplatin.

Keywords: acute kidney injury; biomarkers; circulating microRNA; nephrotoxicity; urinary microRNAs.

© 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.

Shihana, Fathima
Barron, Melissa L.
Mohamed, Fahim
Seth, Devanshi
Buckley, Nicholas A.
Last Modified: 10 Jun 2021 05:49
URI: https://eprints.centenary.org.au/id/eprint/992

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