Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes

Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Journal of the American College of Cardiology
Volume: 77
Number: 20
Page Range: pp. 2517-2530
Date: 2021
Divisions: Molecular Cardiology
Cardio Genomics
Depositing User: General Admin
Identification Number: 10.1016/j.jacc.2020.12.071
ISSN: 07351097
Date Deposited: 10 Jun 2021 05:20

Our understanding of the genetic basis of cardiovascular diseases (CVDs) has evolved rapidly. This has resulted from a combination of dedicated research in well phenotyped CVD patients, the sequencing of the human genome, and the ready accessibility and decreasing cost of next-generation sequencing technologies. This increased knowledge of the genetic basis of CVDs has heralded the era of precision medicine. This encompasses many elements including improved diagnosis, family screening, assistance with reproductive decisions, targeted therapeutics guided by both phenotype and genotype, and providing important insights into risk stratification and prognosis. Furthermore, novel insights into genetic mechanisms, clinical rollout of polygenic risk scores for common CVDs, and the promise of genome editing approaches to effectively cure disease represent some of the exciting future endeavors that will change established clinical approaches. This Part 1 of a 5-part series focuses on the underpinnings and fundamental aspects of precision medicine.

Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Semsarian, Christopher
Ingles, Jodie
Ross, Samantha Barratt
Dunwoodie, Sally L.
Bagnall, Richard D.
Kovacic, Jason C.
Last Modified: 10 Jun 2021 05:20

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