Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes.
Full text not available from this repository.Item Type: | Article |
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Status: | Published |
Official URL: | https://doi.org/10.1016/j.jacc.2020.12.071 |
Journal or Publication Title: | Journal of the American College of Cardiology |
Volume: | 77 |
Number: | 20 |
Page Range: | pp. 2517-2530 |
Date: | 2021 |
Divisions: | Molecular Cardiology Cardio Genomics |
Depositing User: | General Admin |
Identification Number: | 10.1016/j.jacc.2020.12.071 |
ISSN: | 07351097 |
Date Deposited: | 10 Jun 2021 05:20 |
Abstract: | Our understanding of the genetic basis of cardiovascular diseases (CVDs) has evolved rapidly. This has resulted from a combination of dedicated research in well phenotyped CVD patients, the sequencing of the human genome, and the ready accessibility and decreasing cost of next-generation sequencing technologies. This increased knowledge of the genetic basis of CVDs has heralded the era of precision medicine. This encompasses many elements including improved diagnosis, family screening, assistance with reproductive decisions, targeted therapeutics guided by both phenotype and genotype, and providing important insights into risk stratification and prognosis. Furthermore, novel insights into genetic mechanisms, clinical rollout of polygenic risk scores for common CVDs, and the promise of genome editing approaches to effectively cure disease represent some of the exciting future endeavors that will change established clinical approaches. This Part 1 of a 5-part series focuses on the underpinnings and fundamental aspects of precision medicine. Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Creators: | Creators Email Semsarian, Christopher UNSPECIFIED Ingles, Jodie UNSPECIFIED Ross, Samantha Barratt UNSPECIFIED Dunwoodie, Sally L. UNSPECIFIED Bagnall, Richard D. UNSPECIFIED Kovacic, Jason C. UNSPECIFIED |
Last Modified: | 10 Jun 2021 05:20 |
URI: | https://eprints.centenary.org.au/id/eprint/974 |
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