TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1083/jcb.202103105
Journal or Publication Title: Journal of Cell Biology
Volume: 220
Number: 6
Date: 2021
Divisions: Lipid Metabolism and Neurochemistry
Depositing User: General Admin
Identification Number: 10.1083/jcb.202103105
ISSN: 0021-9525
Date Deposited: 10 Jun 2021 05:20
Abstract:

TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER) and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins. Recently, TMEM41B was identified as a crucial host factor for infection by all coronaviruses and flaviviruses. The molecular function of TMEM41B and VMP1, which belong to a large evolutionarily conserved family, remains elusive. Here, we show that TMEM41B and VMP1 are phospholipid scramblases whose deficiency impairs the normal cellular distribution of cholesterol and phosphatidylserine. Their mechanism of action on LD formation is likely to be different from that of seipin. Their role in maintaining cellular phosphatidylserine and cholesterol homeostasis may partially explain their requirement for viral infection. Our results suggest that the proper sorting and distribution of cellular lipids are essential for organelle biogenesis and viral infection.

© 2021 Li et al.

Creators:
Creators
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Li, Yang Emma
UNSPECIFIED
Wang, Yichang
UNSPECIFIED
Du, Ximing
UNSPECIFIED
Zhang, Tizhong
UNSPECIFIED
Mak, Hoi Yin
UNSPECIFIED
Hancock, Sarah E.
UNSPECIFIED
McEwen, Holly
UNSPECIFIED
Pandzic, Elvis
UNSPECIFIED
Whan, Renee M.
UNSPECIFIED
Aw, Yvette Celine
UNSPECIFIED
Lukmantara, Ivan E.
UNSPECIFIED
Yuan, Yiqiong
UNSPECIFIED
Dong, Xiuju
UNSPECIFIED
Don, Anthony
UNSPECIFIED
Turner, Nigel
UNSPECIFIED
Qi, Shiqian
UNSPECIFIED
Yang, Hongyuan
UNSPECIFIED
Last Modified: 10 Jun 2021 05:28
URI: https://eprints.centenary.org.au/id/eprint/973

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