Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.lfs.2021.119436
Journal or Publication Title: Life Sciences
Volume: 276
Page Range: p. 119436
Date: 2021
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.lfs.2021.119436
ISSN: 00243205
Date Deposited: 10 Jun 2021 05:05
Abstract:

Non-small cell lung cancer (NSCLC) is one of the major causes of cancer-related mortality globally. Despite the availability of therapeutic options, the improvement in patient survival is yet to be achieved. Recent advances in natural product (e.g., Rutin) research, therapeutic nanotechnology and especially the combination of both could aid in achieving significant improvements in the treatment or management of NSCLC. In this study, we explore the anti-cancer activity of Rutin-loaded liquid crystalline nanoparticles (LCNs) in an in vitro model where we have employed the A549 human lung epithelial carcinoma cell line. The anti-proliferative activity was determined by MTT and Trypan blue assays, whereas, the anti-migratory activity was evaluated by the scratch wound healing assay and a modified Boyden chamber assay. We also evaluated the anti-apoptotic activity by Annexin V-FITC staining, and the colony formation activity was studied using crystal violet staining. Here, we report that Rutin-LCNs showed promising anti-proliferative and anti-migratory activities. Furthermore, Rutin-LCNs also induced apoptosis in the A549 cells and inhibited colony formation. The findings warrant further detailed and in-depth anti-cancer mechanistic studies of Rutin-LCNs with a focus towards a potential therapeutic option for NSCLC. LCNs may help to enhance the solubility of Rutin used in the treatment of lung cancer and hence enhance the anticancer effect of Rutin.

Copyright © 2021 Elsevier Inc. All rights reserved.

Creators:
Creators
Email
Paudel, Keshav Raj
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Tew, Xin Nee
UNSPECIFIED
Lau, Natalie Jia Xin
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Panneerselvam, Jithendra
UNSPECIFIED
Zeeshan, Farrukh
UNSPECIFIED
Kumar, Pradeep
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Anand, Krishnan
UNSPECIFIED
Singh, Sachin K.
UNSPECIFIED
Jha, Niraj Kumar
UNSPECIFIED
MacLoughlin, Ronan
UNSPECIFIED
Hansbro, Nicole G.
UNSPECIFIED
Liu, Gang
UNSPECIFIED
Shukla, Shakti D.
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 10 Jun 2021 05:05
URI: https://eprints.centenary.org.au/id/eprint/971

Actions (login required)

View Item View Item