MicroRNAs as Biomarker for Breast Cancer

MicroRNAs as Biomarker for Breast Cancer.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.2174/1871530320666200428113051
Journal or Publication Title: Endocrine, Metabolic & Immune Disorders - Drug Targets
Volume: 20
Number: 10
Page Range: pp. 1597-1610
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2174/1871530320666200428113051
ISSN: 18715303
Date Deposited: 18 Mar 2021 10:44
Abstract:

Regardless of advances in detection and treatment, breast cancer affects about 1.5 million women all over the world. Since the last decade, genome-wide association studies (GWAS) have been extensively conducted for breast cancer to define the role of miRNA as a tool for diagnosis, prognosis and therapeutics. MicroRNAs are small, non-coding RNAs that are associated with the regulation of key cellular processes such as cell multiplication, differentiation, and death. They cause a disturbance in the cell physiology by interfering directly with the translation and stability of a targeted gene transcript. MicroRNAs (miRNAs) constitute a large family of non-coding RNAs, which regulate target gene expression and protein levels that affect several human diseases and are suggested as the novel markers or therapeutic targets, including breast cancer. MicroRNA (miRNA) alterations are not only associated with metastasis, tumor genesis but also used as biomarkers for breast cancer diagnosis or prognosis. These are explained in detail in the following review. This review will also provide an impetus to study the role of microRNAs in breast cancer.

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Creators:
Creators
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Aggarwal, Taru
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Gupta, Riya
UNSPECIFIED
Paudel, Keshav Raj
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Perumalsamy, Haribalan
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Maurya, Pawan Kumar
UNSPECIFIED
Last Modified: 19 Mar 2021 04:06
URI: https://eprints.centenary.org.au/id/eprint/967

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