Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin

Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.2174/1871530320666200503053846
Journal or Publication Title: Endocrine, Metabolic & Immune Disorders - Drug Targets
Volume: 20
Number: 10
Page Range: pp. 1590-1596
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2174/1871530320666200503053846
ISSN: 18715303
Date Deposited: 19 Mar 2021 04:03
Abstract:

The application of medicinal plants has captured the interest of researchers in recent times due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products in treating and preventing multiple diseases dates back to ancient history and most of the modern drugs today originated from their significant sources owing to their ability to control multiple targets via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols, which are well known for their various therapeutic benefits. Rutin is considered one of the attractive phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological activities via various underlying molecular mechanisms. It is usually prescribed for various disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic. This review will be beneficial to herbal, biological and molecular scientists in understanding the pharmacological relevance of rutin at the molecular level.

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Creators:
Creators
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Yong, David O.C.
UNSPECIFIED
Saker, Sanggetha R.
UNSPECIFIED
Chellappan, Dinesh K.
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Panneerselvam, Jithendra
UNSPECIFIED
Choudhury, Hira
UNSPECIFIED
Pandey, Manisha
UNSPECIFIED
Chan, Yik L.
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Oliver, Brian G.
UNSPECIFIED
Wark, Peter
UNSPECIFIED
Hansbro, Nicole
UNSPECIFIED
Hsu, Alan
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Zeeshan, Farrukh
UNSPECIFIED
Last Modified: 19 Mar 2021 04:03
URI: https://eprints.centenary.org.au/id/eprint/966

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