Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease

Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.2174/1871527319999200817112427
Journal or Publication Title: CNS & Neurological Disorders - Drug Targets
Volume: 19
Number: 9
Page Range: pp. 698-708
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2174/1871527319999200817112427
ISSN: 18715273
Date Deposited: 19 Mar 2021 04:00
Abstract:

Tobacco smoke is not only a leading cause for chronic obstructive pulmonary disease, cardiovascular disorders, and lung and oral cancers, but also causes neurological disorders such as Alzheimer 's disease. Tobacco smoke consists of more than 4500 toxic chemicals, which form free radicals and can cross blood-brain barrier resulting in oxidative stress, an extracellular amyloid plaque from the aggregation of amyloid β (Aβ) peptide deposition in the brain. Further, respiratory infections such as Chlamydia pneumoniae, respiratory syncytial virus have also been involved in the induction and development of the disease. The necessary information collated on this review has been gathered from various literature published from 1995 to 2019. The review article sheds light on the role of smoking and respiratory infections in causing oxidative stress and neuroinflammation, resulting in Alzheimer's disease (AD). This review will be of interest to scientists and researchers from biological and medical science disciplines, including microbiology, pharmaceutical sciences and the translational researchers, etc. The increasing understanding of the relationship between chronic lung disease and neurological disease is two-fold. First, this would help to identify the risk factors and possible therapeutic interventions to reduce the development and progression of both diseases. Second, this would help to reduce the probable risk of development of AD in the population prone to chronic lung diseases.

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Creators:
Creators
Email
Wadhwa, Ridhima
UNSPECIFIED
Paudel, Keshav Raj
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Shukla, Shakti D.
UNSPECIFIED
Sunkara, Krishna
UNSPECIFIED
Prasher, Parteek
UNSPECIFIED
Panth, Nisha
UNSPECIFIED
Goyal, Rohit
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Aljabali, Alaa AA.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 19 Mar 2021 04:00
URI: https://eprints.centenary.org.au/id/eprint/965

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