Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections

Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1111/dth.13905
Journal or Publication Title: Dermatologic Therapy
Volume: 33
Number: 6
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1111/dth.13905
ISSN: 1396-0296
Date Deposited: 25 Mar 2021 03:57

The incidences of fungal infections have greatly increased over the past few years, particularly in humid and industrialized areas. The severity of such infections ranges from being asymptomatic-mild to potentially life-threatening systemic infections. There are limited classes of drugs that are approved for the treatment of such infections like polyenes, azoles, and echinocandins. Some fungi have developed resistance to these drugs. Therefore, to counter drug resistance, intensive large scale studies on novel targeting strategies and formulations are being conducted, which have gained impetus lately. Conventional formulations have limitations such as higher doses, frequent dosing, and several side effects. Such limiting factors have paved the path for the emergence of nanotechnology and its applications. This further gave formulation scientists the possibility of encapsulating the existing potential drug moieties into nanocarriers, which when loaded into gels or creams provided prolonged release and improved permeation, thus giving on-target effect. This review thus discusses the newer targeting strategies and the role of nanocarriers that could be administered topically for the treatment of various fungal infections. Furthermore, this approach opens newer avenues for continued and sustained research in pharmaceuticals with much more effective outcomes.

© 2020 Wiley Periodicals LLC

Waghule, Tejashree
Sankar, Shridula
Rapalli, Vamshi Krishna
Gorantla, Srividya
Dubey, Sunil Kumar
Chellappan, Dinesh Kumar
Dua, Kamal
Singhvi, Gautam
Last Modified: 25 Mar 2021 03:57
URI: https://eprints.centenary.org.au/id/eprint/959

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