Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study

Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.2217/nnm-2020-0260
Journal or Publication Title: Nanomedicine
Volume: 15
Number: 30
Page Range: pp. 2955-2970
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2217/nnm-2020-0260
ISSN: 1743-5889
Date Deposited: 07 Jan 2021 01:07
Abstract:

Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma.

Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity.

Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1).

Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.

Creators:
Creators
Email
Wong, Jin-Ying
UNSPECIFIED
Yin Ng, Zhao
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Shukla, Shakti D
UNSPECIFIED
Panneerselvam, Jithendra
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Kumar, Pradeep
UNSPECIFIED
Pillay, Viness
UNSPECIFIED
Hsu, Alan
UNSPECIFIED
Hansbro, Nicole G
UNSPECIFIED
Wark, Peter
UNSPECIFIED
Bebawy, Mary
UNSPECIFIED
Hansbro, Philip Michael
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Last Modified: 07 Jan 2021 01:07
URI: https://eprints.centenary.org.au/id/eprint/933

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