Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents

Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.2174/1381612826666200610111013
Journal or Publication Title: Current Pharmaceutical Design
Volume: 26
Number: 36
Page Range: pp. 4580-4590
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.2174/1381612826666200610111013
ISSN: 13816128
Date Deposited: 05 Jan 2021 05:20
Abstract:

Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents.

Keywords: Phytoconstituents; bioavailability; chronic diseases; nanocarriers; nanomedicine; nanoparticles.

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Creators:
Creators
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Ng, Phui Qi
UNSPECIFIED
Ling, Laura Soon Cheau
UNSPECIFIED
Chellian, Jestin
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Panneerselvam, Jithendra
UNSPECIFIED
Kunnath, Anil Philip
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Hansbro, Philip Michael
UNSPECIFIED
Collet, Trudi
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Last Modified: 05 Jan 2021 22:00
URI: https://eprints.centenary.org.au/id/eprint/925

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