Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment

Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Acta Pharmaceutica Sinica B
Volume: 10
Number: 11
Page Range: pp. 2018-2036
Date: 2020
Divisions: Vascular Biology
Depositing User: General Admin
Identification Number: 10.1016/j.apsb.2020.09.014
ISSN: 22113835
Date Deposited: 05 Jan 2021 05:10

Tumor vasculature is characterized by aberrant structure and function, resulting in immune suppressive profiles of tumor microenvironment through limiting immune cell infiltration into tumors, endogenous immune surveillance and immune cell function. Vascular normalization as a novel therapeutic strategy tends to prune some of the immature blood vessels and fortify the structure and function of the remaining vessels, thus improving immune stimulation and the efficacy of immunotherapy. Interestingly, the presence of "immune‒vascular crosstalk" enables the formation of a positive feedback loop between vascular normalization and immune reprogramming, providing the possibility to develop new cancer therapeutic strategies. The applications of nanomedicine in vascular-targeting therapy in cancer have gained increasing attention due to its specific physical and chemical properties. Here, we reviewed the recent advances of effective routes, especially nanomedicine, for normalizing tumor vasculature. We also summarized the development of enhancing nanoparticle-based anticancer drug delivery via the employment of transcytosis and mimicking immune cell extravasation. This review explores the potential to optimize nanomedicine-based therapeutic strategies as an alternative option for cancer treatment.

Keywords: Antiangiogenesis; Immune cells; Immune‒vascular crosstalk; Immunotherapy; Nanoparticles; Transcytosis; Tumor microenvironment; Vascular normalization.

© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Zhao, Yang
Yu, Xiangrong
Li, Jia
Last Modified: 05 Jan 2021 11:08

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