Deep conservation of the enhancer regulatory code in animals

Deep conservation of the enhancer regulatory code in animals.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1126/science.aax8137
Journal or Publication Title: Science
Volume: 370
Number: 6517
Page Range: eaax8137
Date: 2020
Divisions: David Richmond program for Cardiovascular Development
Depositing User: General Admin
Identification Number: 10.1126/science.aax8137
ISSN: 0036-8075
Date Deposited: 05 Jan 2021 05:09
Abstract:

Interactions of transcription factors (TFs) with DNA regulatory sequences, known as enhancers, specify cell identity during animal development. Unlike TFs, the origin and evolution of enhancers has been difficult to trace. We drove zebrafish and mouse developmental transcription using enhancers from an evolutionarily distant marine sponge. Some of these sponge enhancers are located in highly conserved microsyntenic regions, including an Islet enhancer in the Islet-Scaper region. We found that Islet enhancers in humans and mice share a suite of TF binding motifs with sponges, and that they drive gene expression patterns similar to those of sponge and endogenous Islet enhancers in zebrafish. Our results suggest the existence of an ancient and conserved, yet flexible, genomic regulatory syntax that has been repeatedly co-opted into cell type-specific gene regulatory networks across the animal kingdom.

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Creators:
Creators
Email
Wong, Emily S.
UNSPECIFIED
Zheng, Dawei
UNSPECIFIED
Tan, Siew Z.
UNSPECIFIED
Bower, Neil I.
UNSPECIFIED
Garside, Victoria
UNSPECIFIED
Vanwalleghem, Gilles
UNSPECIFIED
Gaiti, Federico
UNSPECIFIED
Scott, Ethan
UNSPECIFIED
Hogan, Benjamin M.
UNSPECIFIED
Kikuchi, Kazu
UNSPECIFIED
McGlinn, Edwina
UNSPECIFIED
Francois, Mathias
UNSPECIFIED
Degnan, Bernard M.
UNSPECIFIED
Last Modified: 05 Jan 2021 05:09
URI: https://eprints.centenary.org.au/id/eprint/916

Actions (login required)

View Item View Item