Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease.

Full text not available from this repository.
Item Type: Article
Official URL: https://doi.org/10.1038/s41467-020-19701-0
Journal or Publication Title: Nature Communications
Volume: 11
Number: 1
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1038/s41467-020-19701-0
ISSN: 2041-1723
Date Deposited: 05 Jan 2021 05:08
Abstract:

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.

Creators:
Creators
Email
Bowerman, Kate L.
UNSPECIFIED
Rehman, Saima Firdous
UNSPECIFIED
Vaughan, Annalicia
UNSPECIFIED
Lachner, Nancy
UNSPECIFIED
Budden, Kurtis F.
UNSPECIFIED
Kim, Richard Y.
UNSPECIFIED
Wood, David L. A.
UNSPECIFIED
Gellatly, Shaan L.
UNSPECIFIED
Shukla, Shakti D.
UNSPECIFIED
Wood, Lisa G.
UNSPECIFIED
Yang, Ian A.
UNSPECIFIED
Wark, Peter A.
UNSPECIFIED
Hugenholtz, Philip
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 05 Jan 2021 05:08
URI: https://eprints.centenary.org.au/id/eprint/914

Actions (login required)

View Item View Item