Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549

Antiproliferative effects of boswellic acids-loaded chitosan nanoparticles on human lung cancer cell line A549.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://pubmed.ncbi.nlm.nih.gov/
Journal or Publication Title: FUTURE MEDICINAL CHEMISTRY
Date: November 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Date Deposited: 05 Jan 2021 05:22
Abstract:

Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized using ionic gelation technique. The influence of independent variables were studied and optimized on dependent variables using central composite design.

Methodology & results: The designed nanoparticles were observed spherical in shape with an average size of 67.5-187.2 nm and have also shown an excellent entrapment efficiency (80.06 ± 0.48). The cytotoxicity assay revealed enhanced cytotoxicity for drug-loaded nanoparticles in contrast to the free drug having an IC50 value of 17.29 and 29.59 μM, respectively. Flow cytometry confirmed that treatment of cells with 40 μg/ml had arrested 22.75 ± 0.3% at SubG0 phase of the cell cycle when compared with untreated A459 cells. The observed results justified the boswellic acids-loaded chitosan nanoparticles were effective due to greater cellular uptake, sustained intercellular drug retention and enhanced antiproliferative effect by inducing apoptosis.

Creators:
Creators
Email
Solanki, Neeta
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Hansbro, Nicole G.
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Aljabali, Alaa A. A.
UNSPECIFIED
Paudel, Keshav Raj
UNSPECIFIED
Liu, Gang
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Last Modified: 05 Jan 2021 05:26
URI: https://eprints.centenary.org.au/id/eprint/910

Actions (login required)

View Item View Item