Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma?

Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma?

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1111/pcmr.12870
Journal or Publication Title: Pigment Cell & Melanoma Research
Volume: 33
Number: 5
Page Range: pp. 660-670
Date: 2020
Divisions: Melanoma Oncology and Immunology
Melanoma Epigenetics Laboratory
Depositing User: General Admin
Identification Number: 10.1111/pcmr.12870
ISSN: 1755-1471
Date Deposited: 22 Dec 2020 03:04
Abstract:

Melanoma, as for many other cancers, undergoes a selection process during progression that limits many innate and adaptive tumor control mechanisms. Immunotherapy with immune checkpoint blockade overcomes one of the escape mechanisms but if the tumor is not eliminated other escape mechanisms evolve that require new approaches for tumor control. Some of the innate mechanisms that have evolved against infections with microorganisms and viruses are proving to be active against cancer cells but require better understanding of how they are activated and what inhibitory mechanisms may need to be targeted. This is particularly so for inflammasomes which have evolved against many different organisms and which recruit a number of cytotoxic mechanisms that remain poorly understood. Equally important is understanding of where these mechanisms will fit into existing treatment strategies and whether existing strategies already involve the innate killing mechanisms.

Creators:
Creators
Email
Emran, Abdullah Al
UNSPECIFIED
Tseng, Hsin‐Yi
UNSPECIFIED
Coleman, Mikaela C.
UNSPECIFIED
Tiffen, Jessamy
UNSPECIFIED
Cook, Stuart
UNSPECIFIED
McGuire, Helen M.
UNSPECIFIED
Gallagher, Stuart
UNSPECIFIED
Feng, Carl
UNSPECIFIED
Hersey, Peter
UNSPECIFIED
Last Modified: 25 Mar 2021 04:16
URI: https://eprints.centenary.org.au/id/eprint/906

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