Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma?
Full text not available from this repository.Item Type: | Review |
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Status: | Published |
Official URL: | https://doi.org/10.1111/pcmr.12870 |
Journal or Publication Title: | Pigment Cell & Melanoma Research |
Volume: | 33 |
Number: | 5 |
Page Range: | pp. 660-670 |
Date: | 2020 |
Divisions: | Melanoma Oncology and Immunology Melanoma Epigenetics Laboratory |
Depositing User: | General Admin |
Identification Number: | 10.1111/pcmr.12870 |
ISSN: | 1755-1471 |
Date Deposited: | 22 Dec 2020 03:04 |
Abstract: | Melanoma, as for many other cancers, undergoes a selection process during progression that limits many innate and adaptive tumor control mechanisms. Immunotherapy with immune checkpoint blockade overcomes one of the escape mechanisms but if the tumor is not eliminated other escape mechanisms evolve that require new approaches for tumor control. Some of the innate mechanisms that have evolved against infections with microorganisms and viruses are proving to be active against cancer cells but require better understanding of how they are activated and what inhibitory mechanisms may need to be targeted. This is particularly so for inflammasomes which have evolved against many different organisms and which recruit a number of cytotoxic mechanisms that remain poorly understood. Equally important is understanding of where these mechanisms will fit into existing treatment strategies and whether existing strategies already involve the innate killing mechanisms. |
Creators: | Creators Email Emran, Abdullah Al UNSPECIFIED Tseng, Hsin‐Yi UNSPECIFIED Coleman, Mikaela C. UNSPECIFIED Tiffen, Jessamy UNSPECIFIED Cook, Stuart UNSPECIFIED McGuire, Helen M. UNSPECIFIED Gallagher, Stuart UNSPECIFIED Feng, Carl UNSPECIFIED Hersey, Peter UNSPECIFIED |
Last Modified: | 25 Mar 2021 04:16 |
URI: | https://eprints.centenary.org.au/id/eprint/906 |
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