Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1111/all.14548
Journal or Publication Title: Allergy
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1111/all.14548
ISSN: 0105-4538
Date Deposited: 22 Dec 2020 03:05
Abstract:

The prevalence of chronic immune and metabolic disorders is increasing rapidly. In particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive pulmonary disease have become major healthcare and economic burdens worldwide. Recent advances in microbiome research have led to significant discoveries of associative links between alterations in the microbiome and health, as well as these chronic supposedly noncommunicable, immune/metabolic disorders. Importantly, the interplay between diet, microbiome and the mucous barrier in these diseases has gained significant attention. Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disease onset/exacerbation due to a “poor” diet or protection against disease with a “healthy” diet. In addition, many mucosa‐associated disorders possess a specific gut microbiome fingerprint associated with the composition of the mucous barrier, which is further influenced by host‐microbiome and inter‐microbial interactions, dietary choices, microbe immigration and antimicrobials. Our review focuses on the interactions of diet (macronutrients and micronutrients), gut microbiota and mucous barriers (gastrointestinal and respiratory tract) and their importance in the onset and/or progression of major immune/metabolic disorders. We also highlight the key mechanisms that could be targeted therapeutically to prevent and/or treat these

Creators:
Creators
Email
Alemao, Charlotte A.
UNSPECIFIED
Budden, Kurtis F.
UNSPECIFIED
Gomez, Henry M.
UNSPECIFIED
Rehman, Saima F.
UNSPECIFIED
Marshall, Jacqueline E.
UNSPECIFIED
Shukla, Shakti D.
UNSPECIFIED
Donovan, Chantal
UNSPECIFIED
Forster, Samuel C.
UNSPECIFIED
Yang, Ian A.
UNSPECIFIED
Keely, Simon
UNSPECIFIED
Mann, Elizabeth R.
UNSPECIFIED
El Omar, Emad M.
UNSPECIFIED
Belz, Gabrielle T.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 05 Jan 2021 11:33
URI: https://eprints.centenary.org.au/id/eprint/904

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