Current perspectives on the tumor microenvironment in hepatocellular carcinoma

Current perspectives on the tumor microenvironment in hepatocellular carcinoma.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Hepatology International
Date: 2020
Divisions: Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1007/s12072-020-10104-3
ISSN: 1936-0533
Date Deposited: 22 Dec 2020 03:27

Hepatocellular carcinoma (HCC) is a heterogeneous inflammation-driven malignancy, which, despite significant advances in management, continues to portend a poor prognosis. Recent advances in basic and translational research have increasingly defined the role of the tumor microenvironment in the development and progression of HCC and facilitated the development of novel molecular targets. The hepatoma microenvironment is characterised by an immunosuppressive milieu of immune cells and tumor vasculature that is both structurally and functionally abnormal. Normalising the tumor microenvironment by adopting a multipronged approach that targets both carcinogenic processes and the immunosuppressive milieu has been supported by pre-clinical and clinical data. In this review, we summarise the current understanding of the hepatoma microenvironment, its influences and dynamic interactions with tumor cells, the vasculature and the gut. Finally, we discuss how manipulating the tumor microenvironment continues to shape the evolving landscape of HCC therapy.

Santhakumar, Cositha
Gane, Edward J.
Liu, Ken
McCaughan, Geoffrey W.
Last Modified: 05 Jan 2021 11:05

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