The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy

The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.3389/fonc.2019.01366
Journal or Publication Title: Frontiers in Oncology
Volume: 9
Date: 2019
Divisions: Gene and Stem Cell Therapy
Depositing User: General Admin
Identification Number: 10.3389/fonc.2019.01366
ISSN: 2234-943X
Date Deposited: 22 Dec 2020 03:14
Abstract:

Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make connection with the outcome of immunotherapy trials.

Creators:
Creators
Email
Chu, Gerard J.
UNSPECIFIED
van Zandwijk, Nico
UNSPECIFIED
Rasko, John E. J.
UNSPECIFIED
Last Modified: 22 Dec 2020 03:14
URI: https://eprints.centenary.org.au/id/eprint/898

Actions (login required)

View Item View Item