Regulation of T Helper Cell Fate by TCR Signal Strength

Regulation of T Helper Cell Fate by TCR Signal Strength.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Frontiers in Immunology
Volume: 11
Date: 2020
Divisions: Tuberculosis
Depositing User: General Admin
Identification Number: 10.3389/fimmu.2020.00624
ISSN: 1664-3224
Date Deposited: 22 Dec 2020 03:24

T cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell activation, division, and clonal expansion in secondary lymphoid organs. T cells must also integrate multiple T cell-intrinsic and extrinsic signals to acquire the effector functions essential for the defense against invading microbes. In the case of T helper cell differentiation, while innate cytokines have been demonstrated to shape effector CD4+ T lymphocyte function, the contribution of TCR signaling strength to T helper cell differentiation is less understood. In this review, we summarize the signaling cascades regulated by the strength of TCR stimulation. Various mechanisms in which TCR signal strength controls T helper cell expansion and differentiation are also discussed.

Bhattacharyya, Nayan D.
Feng, Carl G.
Last Modified: 05 Jan 2021 12:00

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