Cellular mechanisms underlying steroid-resistant asthma

Cellular mechanisms underlying steroid-resistant asthma.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1183/16000617.0096-2019
Journal or Publication Title: European Respiratory Review
Volume: 28
Number: 153
Page Range: p. 190096
Date: 2019
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1183/16000617.0096-2019
ISSN: 0905-9180
Date Deposited: 22 Dec 2020 03:25

Severe steroid-resistant asthma is clinically important, as patients with this form of the disease do not respond to mainstay corticosteroid therapies. The heterogeneity of this form of asthma and poor understanding of the pathological mechanisms involved hinder the identification of therapeutic targets and the development of more effective therapies. A major limiting factor in the understanding of severe steroid-resistant asthma is the existence of multiple endotypes represented by different immunological and inflammatory phenotypes, particularly in adults. Several clinical and experimental studies have revealed associations between specific respiratory infections and steroid-resistant asthma in adults. Here, we discuss recent findings from other authors as well as our own studies that have developed novel experimental models for interrogating the association between respiratory infections and severe steroid-resistant asthma. These models have enabled the identification of new therapies using macrolides, as well as several novel disease mechanisms, including the microRNA-21/phosphoinositide 3-kinase/histone deacetylase 2 axis and NLRP3 inflammasomes, and highlight the potential of these mechanisms as therapeutic targets.

Wadhwa, Ridhima
Dua, Kamal
Adcock, Ian M.
Horvat, Jay C.
Kim, Richard Y.
Hansbro, Philip M.
Last Modified: 22 Dec 2020 03:25
URI: https://eprints.centenary.org.au/id/eprint/893

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