Management of patients with intermediate stage hepatocellular carcinoma

Management of patients with intermediate stage hepatocellular carcinoma.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Therapeutic Advances in Medical Oncology
Volume: 12
Page Range: p. 175883592097084
Date: 2020
Divisions: Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1177/1758835920970840
ISSN: 1758-8359
Date Deposited: 22 Dec 2020 03:28

Hepatocellular carcinoma (HCC) causes a significant health burden globally and its impact is expected to increase in the coming years. Intermediate stage HCC, as defined by the Barcelona Clinic Liver Cancer (BCLC) system stage B, represents up to 30% of patients at diagnosis and encompasses a broad spectrum of tumor burden. Several attempts have been made to further subclassify this heterogenous group. The current standard of care recommended by BCLC for intermediate stage HCC patients is transarterial chemoembolization (TACE), with modest outcomes reported. While refinements have been made to TACE technique and patient selection, it remains non-curative. In the real-world setting, only 60% of patients with intermediate stage HCC receive TACE, with the remainder deviating to a range of other therapies that have shown promise in select patient subgroups. These include curative treatments (resection, ablation, and liver transplantation), radiotherapy (stereotactic and radioembolization), systemic therapies, and their combination. In this review, we summarize the classifications and current management for patients with intermediate stage HCC as well as highlight recent key developments in this space.

Prince, David
Liu, Ken
Xu, Weiqi
Chen, Minjiang
Sun, Jin-Yu
Lu, Xiao-Jie
Ji, Jiansong
Last Modified: 05 Jan 2021 11:24

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