Nanocarriers: more than tour de force for thymoquinone

Nanocarriers: more than tour de force for thymoquinone.

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Item Type: Review
Status: Published
Official URL:
Journal or Publication Title: Expert Opinion on Drug Delivery
Volume: 17
Number: 4
Page Range: pp. 479-494
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1080/17425247.2020.1730808
ISSN: 1742-5247
Date Deposited: 22 Dec 2020 03:37

Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical trials, restricted by its poor biopharmaceutical properties including photo-instability.

Area covered: This review compiles the different types of polymeric and lipidic nanocarriers (NCs), encapsulating TQ for their improved oral bioavailability, and augmented in vitro and in vivo efficacy, evidenced on various pathologies. Furthermore, we provide a comprehensive overview of TQ in relation to its encapsulation approaches advancing the delivery and improving the efficacy of TQ.

Expert opinion: TQ was first identified in the essential oil of Nigella sativa L. black seed. TQ has not been used in formulations because it is a highly hydrophobic drug having poor aqueous solubility. To deal with the poor physicochemical problems associated with TQ, various NCs encapsulating TQ have been tried in the past. Nevertheless, these NCs could be impending in bringing forth this potential molecule to clinical reality. This will also be beneficial for a large research community including pharmaceutical & biological sciences and translational researchers.

Rathore, Charul
Rathbone, Michael J
Chellappan, Dinesh K
Tambuwala, Murtaza M
Pinto, Terezinha De Jesus A
Dureja, Harish
Hemrajani, Chetna
Gupta, Gaurav
Dua, Kamal
Negi, Poonam
Last Modified: 05 Jan 2021 21:54

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