Emerging therapeutic targets and preclinical models for severe asthma

Emerging therapeutic targets and preclinical models for severe asthma.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1080/14728222.2020.1786535
Journal or Publication Title: Expert Opinion on Therapeutic Targets
Volume: 24
Number: 9
Page Range: pp. 845-857
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1080/14728222.2020.1786535
ISSN: 1472-8222
Date Deposited: 22 Dec 2020 03:39

Asthma is a heterogeneous disease with complex multifactorial causes. It is possible to subclassify asthma into different phenotypes that have distinct immunological features. Eosinophilic asthma is a well-known phenotype of severe asthma; however, a large body of clinical and experimental evidence strongly associates persistent airway inflammation, including the accumulation of neutrophils in the bronchial mucosa, and resistance to corticosteroid therapy and non-Type-2 immune responses with severe asthma. Importantly, mainstay therapies are often ineffective in severe asthma and effective alternatives are urgently needed.

Areas covered
Here, we discussed recently developed mouse models of severe asthma that recapitulates key features of the disease in humans. We also provide findings from clinically relevant experimental models that have identified potential therapeutic targets for severe asthma. The most relevant publications on the topic of interest were selected from PubMed.

Expert commentary
Increasing the understanding of disease-causing mechanisms in severe asthma may lead to the identification of novel therapeutic targets and the development of more effective therapies. Intense research interest into investigating the pathophysiological mechanisms of severe asthma has driven the development and interrogation of a myriad of mouse models that aim to replicate hallmark features of severe asthma in humans.

Galvão, Izabela
Kim, Richard Y.
Shen, Sijie
Budden, Kurtis F.
Vieira, Angélica T.
Hansbro, Philip M.
Last Modified: 05 Jan 2021 11:48
URI: https://eprints.centenary.org.au/id/eprint/884

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