Animal and translational models of SARS-CoV-2 infection and COVID-19

Animal and translational models of SARS-CoV-2 infection and COVID-19.

Full text not available from this repository.
Item Type: Review
Status: Published
Official URL: https://doi.org/10.1038/s41385-020-00340-z
Journal or Publication Title: Mucosal Immunology
Volume: 13
Number: 6
Page Range: pp. 877-891
Date: 2020
Divisions: Directed Evolution
Immune Imaging
Liver Enzymes in Metabolism and Inflammation
Liver Injury and Cancer
UTS Centre for Inflammation
Vascular Biology
Depositing User: General Admin
Identification Number: 10.1038/s41385-020-00340-z
ISSN: 1933-0219
Date Deposited: 22 Dec 2020 03:42
Abstract:

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.

Creators:
Creators
Email
Johansen, M. D.
UNSPECIFIED
Irving, A.
UNSPECIFIED
Montagutelli, X.
UNSPECIFIED
Tate, M. D.
UNSPECIFIED
Rudloff, I.
UNSPECIFIED
Nold, M. F.
UNSPECIFIED
Hansbro, N. G.
UNSPECIFIED
Kim, R. Y.
UNSPECIFIED
Donovan, C.
UNSPECIFIED
Liu, G.
UNSPECIFIED
Faiz, A.
UNSPECIFIED
Short, K. R.
UNSPECIFIED
Lyons, J. G.
UNSPECIFIED
McCaughan, G. W.
UNSPECIFIED
Gorrell, M. D.
UNSPECIFIED
Cole, A.
UNSPECIFIED
Moreno, C.
UNSPECIFIED
Couteur, D.
UNSPECIFIED
Hesselson, D.
UNSPECIFIED
Triccas, J.
UNSPECIFIED
Neely, G. G.
UNSPECIFIED
Gamble, J. R.
UNSPECIFIED
Simpson, S. J.
UNSPECIFIED
Saunders, B. M.
UNSPECIFIED
Oliver, B. G.
UNSPECIFIED
Britton, W. J.
UNSPECIFIED
Wark, P. A.
UNSPECIFIED
Nold-Petry, C. A.
UNSPECIFIED
Hansbro, P. M.
UNSPECIFIED
Last Modified: 05 Jan 2021 11:34
URI: https://eprints.centenary.org.au/id/eprint/882

Actions (login required)

View Item View Item