Molecular mechanisms of action of naringenin in chronic airway diseases

Molecular mechanisms of action of naringenin in chronic airway diseases.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1016/j.ejphar.2020.173139
Journal or Publication Title: European Journal of Pharmacology
Volume: 879
Page Range: p. 173139
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.ejphar.2020.173139
ISSN: 00142999
Date Deposited: 22 Dec 2020 03:48
Abstract:

Chronic airway inflammatory diseases are characterized by persistent proinflammatory responses in the respiratory tract. Although, several treatment strategies are currently available, lifelong therapy is necessary for most of these diseases. In recent years, phytophenols, namely, flavonoids, derived from fruits and vegetables have been gaining tremendous interest and have been extensively studied due to their low toxicological profile. Naringenin is a bioflavonoid abundantly found in citrus fruits. This substance has shown notable therapeutic potential in various diseases due to its promising diverse biological activities. In this review, we have attempted to review the published studies from the available literature, discussing the molecular level mechanisms of naringenin in different experimental models of airway inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, pulmonary fibrosis and cystic fibrosis. Current evidences have proposed that the anti-inflammatory properties of naringenin play a major role in ameliorating inflammatory disease states. In addition, naringenin also possesses several other biological properties. Despite the proposed mechanisms suggesting remarkable therapeutic benefits, the clinical use of naringenin is, however, hampered by its low solubility and bioavailability. Furthermore, this review also discusses on the studies that utilise nanocarriers as a drug delivery system to address the issue of poor solubility.

Creators:
Creators
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Chin, Li Hian
UNSPECIFIED
Hon, Chian Ming
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Chellian, Jestin
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Zeeshan, Farrukh
UNSPECIFIED
Awasthi, Rajendra
UNSPECIFIED
Aljabali, Alaa AA.
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Kapoor, Deepak N.
UNSPECIFIED
Goyal, Rohit
UNSPECIFIED
Paudel, Keshav Raj
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Hsu, Alan
UNSPECIFIED
Wark, Peter
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Hansbro, Philip Michael
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 05 Jan 2021 11:44
URI: https://eprints.centenary.org.au/id/eprint/877

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