Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease

Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1016/j.cbi.2020.108975
Journal or Publication Title: Chemico-Biological Interactions
Volume: 317
Page Range: p. 108975
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.cbi.2020.108975
ISSN: 00092797
Date Deposited: 22 Dec 2020 03:50
Abstract:

In patients with acute kidney injury progressively converting into chronic kidney disease (CKD), proteinuria and high blood pressure predict progression to end-stage renal disease (ESRD). Although, Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and kidney disease through both direct and indirect mechanisms. RAAS blockers that act at the level of angiotensin or lower in the cascade can cause compensatory increases in the plasma renin and angiotensin II level. Here, in this review article, we are exploring the evidence-based on RAAS blockade action releases of aldosterone and hypothesizing the molecular mechanism for converting the acute kidney injury into chronic kidney disease to end-stage renal disease.

Creators:
Creators
Email
Gupta, Gaurav
UNSPECIFIED
Dahiya, Rajiv
UNSPECIFIED
Singh, Yogendra
UNSPECIFIED
Mishra, Anurag
UNSPECIFIED
Verma, Aseem
UNSPECIFIED
Gothwal, Sunil Kumar
UNSPECIFIED
Aljabali, Alaa A.A.
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Prasher, Parteek
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Kapoor, Deepak N.
UNSPECIFIED
Goyal, Rohit
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Chellappan, Dinesh K.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 05 Jan 2021 21:57
URI: https://eprints.centenary.org.au/id/eprint/875

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