Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer’s disease etiology

Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer’s disease etiology.

Full text not available from this repository.
Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.bbi.2019.10.014
Journal or Publication Title: Brain, Behavior, and Immunity
Volume: 83
Page Range: pp. 22-32
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1016/j.bbi.2019.10.014
ISSN: 08891591
Date Deposited: 22 Dec 2020 03:51
Abstract:

Alzheimer’s disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has focused on infectious pathogens that may colonize the brain such as herpes simplex type I. Some researchers have proposed the respiratory bacteria Chlamydia pneumoniae may also be implicated in Alzheimer’s disease, however this remains controversial. This review aims to provide a balanced overview of the current evidence and its limitations and future approaches that may resolve controversies. We discuss the evidence from in vitro, animal and human studies proposed to implicate Chlamydia pneumoniae in Alzheimer’s disease and other neurological conditions, the potential mechanisms by which the bacterium may contribute to pathogenesis and limitations of previous studies that may explain the inconsistencies in the literature.

Creators:
Creators
Email
Woods, Jason J.
UNSPECIFIED
Skelding, Kathryn A.
UNSPECIFIED
Martin, Kristy L.
UNSPECIFIED
Aryal, Ritambhara
UNSPECIFIED
Sontag, Estelle
UNSPECIFIED
Johnstone, Daniel M.
UNSPECIFIED
Horvat, Jay C.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Milward, Elizabeth A.
UNSPECIFIED
Last Modified: 22 Dec 2020 03:51
URI: https://eprints.centenary.org.au/id/eprint/874

Actions (login required)

View Item View Item