Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1007/s13346-020-00789-2
Journal or Publication Title: Drug Delivery and Translational Research
Volume: 10
Number: 5
Page Range: pp. 1171-1190
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1007/s13346-020-00789-2
ISSN: 2190-393X
Date Deposited: 22 Dec 2020 03:51
Abstract:

Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis.

Creators:
Creators
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Sharma, Abhishek Kumar
UNSPECIFIED
Prasher, Parteek
UNSPECIFIED
Aljabali, Alaa A.
UNSPECIFIED
Mishra, Vijay
UNSPECIFIED
Gandhi, Himanshu
UNSPECIFIED
Kumar, Sunil
UNSPECIFIED
Mutalik, Srinivas
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Kapoor, Deepak N.
UNSPECIFIED
Last Modified: 05 Jan 2021 11:55
URI: https://eprints.centenary.org.au/id/eprint/873

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