Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1007/s10787-020-00698-3
Journal or Publication Title: Inflammopharmacology
Volume: 28
Number: 4
Page Range: pp. 795-817
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1007/s10787-020-00698-3
ISSN: 0925-4692
Date Deposited: 22 Dec 2020 03:52
Abstract:

Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases involve multiple pulmonary components, including airways and lungs that lead to their abnormal physiological functioning. Several signaling pathways have been reported to play an important role in the pathophysiology of respiratory diseases. These pathways, in addition, become the compounding factors contributing to the clinical outcomes in respiratory diseases. A range of signaling components such as Notch, Hedgehog, Wingless/Wnt, bone morphogenetic proteins, epidermal growth factor and fibroblast growth factor is primarily employed by these pathways in the eventual cascade of events. The different aberrations in such cell-signaling processes trigger the onset of respiratory diseases making the conventional therapeutic modalities ineffective. These challenges have prompted us to explore novel and effective approaches for the prevention and/or treatment of respiratory diseases. In this review, we have attempted to deliberate on the current literature describing the role of major cell signaling pathways in the pathogenesis of pulmonary diseases and discuss promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing pulmonary vascular pathology in such patients.

Creators:
Creators
Email
Mehta, Meenu
UNSPECIFIED
Dhanjal, Daljeet S.
UNSPECIFIED
Paudel, Keshav R.
UNSPECIFIED
Singh, Bhupender
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Rajeshkumar, S.
UNSPECIFIED
Thangavelu, Lakshmi
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Bakshi, Hamid A.
UNSPECIFIED
Chellappan, Dinesh K.
UNSPECIFIED
Pandey, Parijat
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Charbe, Nitin B.
UNSPECIFIED
Singh, Sachin K.
UNSPECIFIED
Shukla, Shakti D.
UNSPECIFIED
Nammi, Srinivas
UNSPECIFIED
Aljabali, Alaa A.
UNSPECIFIED
Wich, Peter R.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 05 Jan 2021 21:48
URI: https://eprints.centenary.org.au/id/eprint/872

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