The role of the microbiome and the NLRP3 inflammasome in the gut and lung

The role of the microbiome and the NLRP3 inflammasome in the gut and lung.

Full text not available from this repository.
Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/JLB.3MR0720-472RR
Journal or Publication Title: Journal of Leukocyte Biology
Volume: 108
Number: 3
Page Range: pp. 925-935
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/JLB.3MR0720-472RR
ISSN: 0741-5400
Date Deposited: 22 Dec 2020 03:58
Abstract:

The nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) family, pyrin domain‐containing protein 3 (NLRP3) inflammasome, is one of the most well‐characterized inflammasomes, activated by pathogen‐associated molecular patterns and damage‐associated molecular patterns, including from commensal or pathogenic bacterial and viral infections. The NLRP3 inflammasome promotes inflammatory cell recruitment and regulates immune responses in tissues such as the gastrointestinal tract and the lung, and is involved in many diseases that affect the gut and lung. Recently, the microbiome in the gut and the lung, and the crosstalk between these organs (gut–lung axis), has been identified as a potential mechanism that may influence disease in a bidirectional manner. In this review, we focus on themes presented in this area at the 2019 World Congress on Inflammation. We discuss recent evidence on how the microbiome can affect NLRP3 inflammasome responses in the gut and lung, the role of this inflammasome in regulating gut and lung inflammation in disease, and its potential role in the gut–lung axis. We highlight the exponential increase in our understanding of the NLRP3 inflammasome due to the synthesis of the NLRP3 inflammasome inhibitor, MCC950, and propose future studies that may further elucidate the roles of the NLRP3 inflammasome in gut and lung diseases.

Creators:
Creators
Email
Donovan, Chantal
UNSPECIFIED
Liu, Gang
UNSPECIFIED
Shen, Sj
UNSPECIFIED
Marshall, Jacqueline E.
UNSPECIFIED
Kim, Richard Y.
UNSPECIFIED
Alemao, Charlotte A.
UNSPECIFIED
Budden, Kurtis F.
UNSPECIFIED
Choi, Jaesung P.
UNSPECIFIED
Kohonen‐Corish, Maija
UNSPECIFIED
El‐Omar, Emad M.
UNSPECIFIED
Yang, Ian A.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Last Modified: 05 Jan 2021 11:35
URI: https://eprints.centenary.org.au/id/eprint/871

Actions (login required)

View Item View Item