Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review

Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review.

Full text not available from this repository.
Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/ddr.21704
Journal or Publication Title: Drug Development Research
Volume: 81
Number: 7
Page Range: pp. 837-858
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/ddr.21704
ISSN: 0272-4391
Date Deposited: 22 Dec 2020 03:59
Abstract:

Majority of the representative drugs customarily interact with multiple targets manifesting unintended side effects. In addition, drug resistance and over expression of the cellular efflux‐pumps render certain classes of drugs ineffective. With only a few innovative formulations in development, it is necessary to identify pharmacophores and novel strategies for creating new drugs. The conjugation of dissimilar pharmacophoric moieties to design hybrid molecules with an attractive therapeutic profile is an emerging paradigm in the contemporary drug development regime. The recent decade witnessed the remarkable biological potential of 1,3,5‐triazine framework in the development of various chemotherapeutics. The appending of the 1,3,5‐triazine nucleus to biologically relevant moieties has delivered exciting results. The present review focuses on 1,3,5‐triazine based hybrid molecules in the development of pharmaceuticals.

Creators:
Creators
Email
Prasher, Parteek
UNSPECIFIED
Sharma, Mousmee
UNSPECIFIED
Aljabali, Alaa A. A.
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Kapoor, Deepak N.
UNSPECIFIED
Singh, Inderbir
UNSPECIFIED
Zacconi, Flavia C.
UNSPECIFIED
Jesus Andreoli Pinto, Terezinha
UNSPECIFIED
Silva, Mateus Webba
UNSPECIFIED
Bakshi, Hamid A.
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 05 Jan 2021 11:51
URI: https://eprints.centenary.org.au/id/eprint/870

Actions (login required)

View Item View Item