Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases

Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases.

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Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/ddr.21648
Journal or Publication Title: Drug Development Research
Volume: 81
Number: 4
Page Range: pp. 419-436
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1002/ddr.21648
ISSN: 0272-4391
Date Deposited: 22 Dec 2020 04:00
Abstract:

Neutrophils are essential effector cells of immune system for clearing the extracellular pathogens during inflammation and immune reactions. Neutrophils play a major role in chronic respiratory diseases. In respiratory diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, lung cancer and others, there occurs extreme infiltration and activation of neutrophils followed by a cascade of events like oxidative stress and dysregulated cellular proteins that eventually result in apoptosis and tissue damage. Dysregulation of neutrophil effector functions including delayed neutropil apoptosis, increased neutrophil extracellular traps in the pathogenesis of asthma, and chronic obstructive pulmonary disease enable neutrophils as a potential therapeutic target. Accounting to their role in pathogenesis, neutrophils present as an excellent therapeutic target for the treatment of chronic respiratory diseases. This review highlights the current status and the emerging trends in novel drug delivery systems such as nanoparticles, liposomes, microspheres, and other newer nanosystems that can target neutrophils and their molecular pathways, in the airways against infections, inflammation, and cancer. These drug delivery systems are promising in providing sustained drug delivery, reduced therapeutic dose, improved patient compliance, and reduced drug toxicity. In addition, the review also discusses emerging strategies and the future perspectives in neutrophil‐based therapy.

Creators:
Creators
Email
Chellappan, Dinesh K.
UNSPECIFIED
Yee, Lim W.
UNSPECIFIED
Xuan, Kong Y.
UNSPECIFIED
Kunalan, Kishen
UNSPECIFIED
Rou, Lim C.
UNSPECIFIED
Jean, Leong S.
UNSPECIFIED
Ying, Lee Y.
UNSPECIFIED
Wie, Lee X.
UNSPECIFIED
Chellian, Jestin
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Singh, Sachin K.
UNSPECIFIED
Gulati, Monica
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Da Silva, Mateus Webba
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Paudel, Keshav R.
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Last Modified: 05 Jan 2021 21:55
URI: https://eprints.centenary.org.au/id/eprint/869

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