Utility of genetic testing in athletes

Utility of genetic testing in athletes.

Full text not available from this repository.
Item Type: Review
Status: Published
Official URL: https://doi.org/10.1002/clc.23289
Journal or Publication Title: Clinical Cardiology
Volume: 43
Number: 8
Page Range: pp. 915-920
Date: 2020
Divisions: Molecular Cardiology
Depositing User: General Admin
Identification Number: 10.1002/clc.23289
ISSN: 0160-9289
Date Deposited: 22 Dec 2020 04:01

Athletes are some of the fittest members of our society, yet paradoxically carry an increased risk of sudden cardiac death (SCD). The athlete's underlying risk of SCD in sports may be increased due to a number of underlying structural, arrhythmic and inherited cardiac conditions (ICCs). There are also physiological adaptations, which occur in the cardiovascular system in athletes as a result of high‐level athletic activity and may be misinterpreted as pathology. Differentiation of “athlete's heart” from heart disease may be challenging due to the effects of exercise on the electrical and structural cardiac remodeling. Features such as prolongation of the QT interval, left ventricular hypertrophy and cavity dilatation, create significant overlap between physiology and inherited channelopathies and cardiomyopathies. Most inherited cardiac conditions have an underlying genetic basis to disease and genetic testing in an athlete can have diagnostic, prognostic and therapeutic implications, including guiding exercise recommendations. Therefore, genetic testing can be a useful diagnostic tool when used carefully and appropriately by a trained cardio‐genetics expert.

Gray, Belinda
Semsarian, Christopher
Last Modified: 05 Jan 2021 21:59
URI: https://eprints.centenary.org.au/id/eprint/868

Actions (login required)

View Item View Item