A zebrafish model of tuberculosis comorbidity and the effects of HIF‐activating intervention

A zebrafish model of tuberculosis comorbidity and the effects of HIF‐activating intervention.

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Item Type: Editorial Material
Status: Published
Official URL: https://doi.org/10.1111/febs.15463
Journal or Publication Title: The FEBS Journal
Volume: 287
Number: 18
Page Range: pp. 3917-3920
Date: 2020
Divisions: Immune-Vascular Interactions
Depositing User: General Admin
Identification Number: 10.1111/febs.15463
ISSN: 1742-464X
Date Deposited: 03 Jan 2021 23:39
Abstract:

Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia‐inducible factor‐1α activation as an example of a host‐directed therapy. This platform is a new paradigm for the zebrafish–M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies.

Creators:
Creators
Email
Oehlers, Stefan H.
UNSPECIFIED
Hortle, Elinor
UNSPECIFIED
Cook, Kristina M.
UNSPECIFIED
Last Modified: 05 Jan 2021 11:47
URI: https://eprints.centenary.org.au/id/eprint/849

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