Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma

Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1080/00914037.2020.1765350
Journal or Publication Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Page Range: pp. 1-10
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1080/00914037.2020.1765350
ISSN: 0091-4037
Date Deposited: 03 Jan 2021 23:52
Abstract:

The present study aimed to formulate celastrol into liquid crystalline nanoparticles (LCNPs) through ultrasonication to enhance its therapeutic efficacy in the treatment of asthma. The physiochemical characteristics, in-vitro release studies were determined along with molecular simulations. Celastrol-loaded LCNPs showed the mean particle size of 194.1 ± 9.78 nm and high entrapment efficiency of 99.1 ± 0.02%. TEM revealed cubical-like structure of the nanoparticles and in-vitro release study demonstrated sustained drug release. They also demonstrated significant activity in reducing IL-1β production, when evaluated using immortalized human bronchial epithelial cell lines (BCi-NS1.1), that may help alleviate the symptoms of asthma.

Creators:
Creators
Email
Chan, Yinghan
UNSPECIFIED
Ng, Sin Wi
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Madheswaran, Thiagarajan
UNSPECIFIED
Zeeshan, Farrukh
UNSPECIFIED
Kumar, Pradeep
UNSPECIFIED
Pillay, Viness
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Wadhwa, Ridhima
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Wark, Peter
UNSPECIFIED
Hsu, Alan
UNSPECIFIED
Hansbro, Nicole G
UNSPECIFIED
Hansbro, Philip Michael
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Panneerselvam, Jithendra
UNSPECIFIED
Last Modified: 03 Jan 2021 23:52
URI: https://eprints.centenary.org.au/id/eprint/832

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