Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1615/CritRevEukaryotGeneExpr.20...
Journal or Publication Title: Critical Reviews in Eukaryotic Gene Expression
Volume: 30
Number: 3
Page Range: pp. 245-252
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1615/CritRevEukaryotGeneExpr.2020033451
ISSN: 1045-4403
Date Deposited: 04 Jan 2021 00:31
Abstract:

Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.

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Altamish, Mohammad
UNSPECIFIED
Dahiya, Rajiv
UNSPECIFIED
Singh, Avinash Kumar
UNSPECIFIED
Mishra, Anurag
UNSPECIFIED
Aljabali, Alaa A. A.
UNSPECIFIED
Satija, Saurabh
UNSPECIFIED
Mehta, Meenu
UNSPECIFIED
Dureja, Harish
UNSPECIFIED
Prasher, Parteek
UNSPECIFIED
Negi, Poonam
UNSPECIFIED
Kapoor, Deepak N.
UNSPECIFIED
Goyal, Rohit
UNSPECIFIED
Tambuwala, Murtaza M.
UNSPECIFIED
Chellappan, Dinesh Kumar
UNSPECIFIED
Dua, Kamal
UNSPECIFIED
Gupta, Gaurav
UNSPECIFIED
Last Modified: 04 Jan 2021 00:31
URI: https://eprints.centenary.org.au/id/eprint/811

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