Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1183/13993003.02320-2019
Journal or Publication Title: European Respiratory Journal
Page Range: p. 1902320
Date: 2020
Divisions: UTS Centre for Inflammation
Depositing User: General Admin
Identification Number: 10.1183/13993003.02320-2019
ISSN: 0903-1936
Date Deposited: 04 Jan 2021 00:47
Abstract:

Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.

Creators:
Creators
Email
Gosens, Reinoud
UNSPECIFIED
Hiemstra, Pieter S.
UNSPECIFIED
Adcock, Ian M.
UNSPECIFIED
Bracke, Ken R.
UNSPECIFIED
Dickson, Robert P.
UNSPECIFIED
Hansbro, Philip M.
UNSPECIFIED
Krauss-Etschmann, Susanne
UNSPECIFIED
Smits, Hermelijn H.
UNSPECIFIED
Stassen, Frank R.M.
UNSPECIFIED
Bartel, Sabine
UNSPECIFIED
Last Modified: 04 Jan 2021 00:47
URI: https://eprints.centenary.org.au/id/eprint/800

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