CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma

CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1136/jitc-2019-000452
Journal or Publication Title: Journal for ImmunoTherapy of Cancer
Volume: 8
Number: 1
Page Range: e000452
Date: 2020
Divisions: Human Viral and Cancer Immunology
Tuberculosis
Depositing User: General Admin
Identification Number: 10.1136/jitc-2019-000452
ISSN: 2051-1426
Date Deposited: 04 Jan 2021 01:31
Abstract:

Background Human Papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) is one of the fastest growing cancers in the Western world. When compared to OPSCCs induced by smoking or alcohol, patients with HPV+ OPSCC, have better survival and the mechanisms remain unclear.

Methods The Cancer Genome Atlas (TCGA) database was examined for genes associated with tissue-resident CD8+ T cells. Multiplex immunohistochemistry (IHC) staining was performed on tumor specimen taken from 35 HPV+ and 27 HPV- OPSCC patients.

Results TCGA database revealed that the expression of genes encoding CD103 and CD69 were significantly higher in HPV+ head and neck SCCs (HNSCC) than in HPV- HNSCC. Higher expression levels of these two genes were also associated with better overall survival. IHC staining showed that the proportion of CD103+ tumor-resident CD8+ T cells were significantly higher in HPV+ OPSCCs when compared to HPV- OPSCC. This higher level was also associated with both lower risk of loco-regional failure, and better overall survival. Importantly, patients with HPV- OPSCC who had comparable levels of CD103+ tumor-resident CD8+ T cells to those with HPV+ OPSCC demonstrated similar survival as those with HPV+OPSCC.

Conclusion Our results show that CD103+ tumor-resident CD8+ T cells are critical for protective immunity in both types of OPSCCs. Our data further suggest that the enhanced local protective immunity provided by tumor-resident T cell responses is the underlying factor driving favorable clinical outcomes in HPV+ OPSCCs over HPV- OPSCCs.

Creators:
Creators
Email
Hewavisenti, Rehana
UNSPECIFIED
Ferguson, Angela
UNSPECIFIED
Wang, Kevin
UNSPECIFIED
Jones, Deanna
UNSPECIFIED
Gebhardt, Thomas
UNSPECIFIED
Edwards, Jarem
UNSPECIFIED
Zhang, Mei
UNSPECIFIED
Britton, Warwick
UNSPECIFIED
Yang, Jean
UNSPECIFIED
Hong, Angela
UNSPECIFIED
Palendira, Umaimainthan
UNSPECIFIED
Last Modified: 04 Jan 2021 01:31
URI: https://eprints.centenary.org.au/id/eprint/782

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