A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.chom.2020.04.010
Journal or Publication Title: Cell Host & Microbe
Volume: 27
Number: 6
Page Range: 950-962.e7
Date: 2020
Divisions: Liver Immunology
Depositing User: General Admin
Identification Number: 10.1016/j.chom.2020.04.010
ISSN: 19313128
Date Deposited: 04 Jan 2021 03:35
Abstract:

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter and can mediate efficient protection against liver-stage Plasmodium infection. This finding has prompted the development of immunization strategies where T cells are activated in the spleen and then trapped in the liver to form TRM cells. Here, we identify PbRPL6120-127, a H2-Kb-restricted epitope from the putative 60S ribosomal protein L6 (RPL6) of Plasmodium berghei ANKA, as an optimal antigen for endogenous liver TRM cell generation and protection against malaria. A single dose vaccination targeting RPL6 provided effective and prolonged sterilizing immunity against high dose sporozoite challenges. Expressed throughout the parasite life cycle, across Plasmodium species, and highly conserved, RPL6 exhibits strong translation potential as a vaccine candidate. This is further advocated by the identification of a broadly conserved, immunogenic HLA-A∗02:01-restricted epitope in P. falciparum RPL6.

Creators:
Creators
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Valencia-Hernandez, Ana Maria
UNSPECIFIED
Ng, Wei Yi
UNSPECIFIED
Ghazanfari, Nazanin
UNSPECIFIED
Ghilas, Sonia
UNSPECIFIED
de Menezes, Maria N.
UNSPECIFIED
Holz, Lauren E.
UNSPECIFIED
Huang, Cheng
UNSPECIFIED
English, Kieran
UNSPECIFIED
Naung, Myo
UNSPECIFIED
Tan, Peck Szee
UNSPECIFIED
Tullett, Kirsteen M.
UNSPECIFIED
Steiner, Thiago M.
UNSPECIFIED
Enders, Matthias H.
UNSPECIFIED
Beattie, Lynette
UNSPECIFIED
Chua, Yu Cheng
UNSPECIFIED
Jones, Claerwen M.
UNSPECIFIED
Cozijnsen, Anton
UNSPECIFIED
Mollard, Vanessa
UNSPECIFIED
Cai, Yeping
UNSPECIFIED
Bowen, David G.
UNSPECIFIED
Purcell, Anthony W.
UNSPECIFIED
La Gruta, Nicole L.
UNSPECIFIED
Villadangos, Jose A.
UNSPECIFIED
de Koning-Ward, Tania
UNSPECIFIED
Barry, Alyssa E.
UNSPECIFIED
Barchet, Winfried
UNSPECIFIED
Cockburn, Ian A.
UNSPECIFIED
McFadden, Geoffrey I.
UNSPECIFIED
Gras, Stephanie
UNSPECIFIED
Lahoud, Mireille H.
UNSPECIFIED
Bertolino, Patrick
UNSPECIFIED
Schittenhelm, Ralf B.
UNSPECIFIED
Caminschi, Irina
UNSPECIFIED
Heath, William R.
UNSPECIFIED
Fernandez-Ruiz, Daniel
UNSPECIFIED
Last Modified: 04 Jan 2021 03:35
URI: https://eprints.centenary.org.au/id/eprint/737

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