PGC1α Controls Sucrose Taste Sensitization in Drosophila

PGC1α Controls Sucrose Taste Sensitization in Drosophila.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.celrep.2020.03.044
Journal or Publication Title: Cell Reports
Volume: 31
Number: 1
Page Range: p. 107480
Date: 2020
Divisions: Directed Evolution
Depositing User: General Admin
Identification Number: 10.1016/j.celrep.2020.03.044
ISSN: 22111247
Date Deposited: 04 Jan 2021 03:36
Abstract:

Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive to extrinsic factors like diet, and this occurs by unknown mechanisms. Here, we describe an unbiased proteomic investigation into sweet taste sensitivity in the fruit fly. We identify a dopamine/cyclic AMP (cAMP)/CREB axis acting within sweet taste neurons that controls taste perception but is largely dispensable for acute taste transduction. This pathway modulates sweet taste perception in response to both sensory- and nutrient-restricted diets and converges on PGC1α, a critical regulator of metabolic health and lifespan. By electrophysiology, we found that enhanced sucrose taste sensitivity was the result of heightened sweet taste intensity and that PGC1α was both necessary and sufficient for this effect. Together, we provide the first molecular insight into how diet-induced taste perception is regulated within the sweet taste neuron.

Creators:
Creators
Email
Wang, Qiao-Ping
UNSPECIFIED
Lin, Yong Qi
UNSPECIFIED
Lai, Mei-Ling
UNSPECIFIED
Su, Zhiduan
UNSPECIFIED
Oyston, Lisa J.
UNSPECIFIED
Clark, Teleri
UNSPECIFIED
Park, Scarlet J.
UNSPECIFIED
Khuong, Thang M.
UNSPECIFIED
Lau, Man-Tat
UNSPECIFIED
Shenton, Victoria
UNSPECIFIED
Shi, Yan-Chuan
UNSPECIFIED
James, David E.
UNSPECIFIED
Ja, William W.
UNSPECIFIED
Herzog, Herbert
UNSPECIFIED
Simpson, Stephen J.
UNSPECIFIED
Neely, G. Gregory
UNSPECIFIED
Last Modified: 04 Jan 2021 03:36
URI: https://eprints.centenary.org.au/id/eprint/736

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