Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys

Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1371/journal.ppat.1008262
Journal or Publication Title: PLOS Pathogens
Volume: 16
Number: 1
Page Range: e1008262
Date: 2020
Subjects: Fields of Research > 06 BIOLOGICAL SCIENCES > 0605 MICROBIOLOGY > 060506 Virology
06 BIOLOGICAL SCIENCES > 0605 MICROBIOLOGY > 060506 Virology
Depositing User: Mr Nick Keilar
Identification Number: 10.1371/journal.ppat.1008262
ISSN: 1553-7374
Date Deposited: 31 Jul 2020 04:49
Abstract:

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify “p10” and “p15” as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

Creators:
Creators
Email
Qiu, Jianming
UNSPECIFIED
Lee, Quintin
UNSPECIFIED
Padula, Matthew P.
UNSPECIFIED
Pinello, Natalia
UNSPECIFIED
Williams, Simon H.
UNSPECIFIED
O'Rourke, Matthew B.
UNSPECIFIED
Fumagalli, Marcilio Jorge
UNSPECIFIED
Orkin, Joseph D.
UNSPECIFIED
Song, Renhua
UNSPECIFIED
Shaban, Babak
UNSPECIFIED
Brenner, Ori
UNSPECIFIED
Pimanda, John E.
UNSPECIFIED
Weninger, Wolfgang
UNSPECIFIED
Souza, William Marciel de
UNSPECIFIED
Melin, Amanda D.
UNSPECIFIED
Wong, Justin J.-L.
UNSPECIFIED
Crim, Marcus J.
UNSPECIFIED
Monette, Sébastien
UNSPECIFIED
Roediger, Ben
UNSPECIFIED
Jolly, Christopher J.
UNSPECIFIED
Last Modified: 31 Jul 2020 04:51
URI: https://eprints.centenary.org.au/id/eprint/7

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