Aberrant expression of enzymes regulating m6A mRNA methylation: implication in cancer

Aberrant expression of enzymes regulating m6A mRNA methylation: implication in cancer.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.20892/j.issn.2095-3941.2018.036...
Journal or Publication Title: Cancer Biology & Medicine
Volume: 15
Number: 4
Page Range: p. 323
Date: 2018
Divisions: Epigenetics and RNA Biology
Depositing User: General Admin
Identification Number: 10.20892/j.issn.2095-3941.2018.0365
ISSN: 2095-3941
Date Deposited: 04 Jan 2021 04:23

N6-methyladenosine (m6A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m6A methylation has been implicated in thedevelopment and maintenance of diverse human cancers. Altered m6A levels affect RNA processing, mRNA degradation, andtranslation of mRNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. Recent studieshave reported that the abnormal expression of m6A regulatory enzymes affects m6A abundance and consequently dysregulates theexpression of tumor suppressor genes and oncogenes, including MYC, SOCS2, ADAM19, and PTEN. In this review, we discuss thespecific roles of m6A “writers", “erasers”, and “readers” in normal physiology and how their altered expression promotestumorigenesis. We also describe the potential of exploiting the aberrant expression of these enzymes for cancer diagnosis,prognosis, and the development of novel therapies.

Natalia, Pinello
Stephanie, Sun
Justin, Jong-Leong Wong
Last Modified: 04 Jan 2021 04:23
URI: https://eprints.centenary.org.au/id/eprint/620

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