Noncanonical Hippo Signalling in the Regulation of Leukocyte Function

Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.

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Item Type: Article
Status: Published
Official URL:
Journal or Publication Title: Trends in Immunology
Volume: 39
Number: 8
Page Range: pp. 656-669
Date: 2018
Divisions: Immune Imaging
Science Support
Depositing User: General Admin
Identification Number: 10.1016/
ISSN: 14714906
Date Deposited: 04 Jan 2021 05:06

The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions.

Kurz, Angela R.M.
Catz, Sergio D.
Sperandio, Markus
Last Modified: 04 Jan 2021 05:06

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