Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC

Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1007/978-981-10-8684-7_2
Volume: 1061
Page Range: pp. 3-18
Date: 2018
Divisions: Liver Injury and Cancer
Depositing User: General Admin
Identification Number: 10.1007/978-981-10-8684-7_2
ISSN: 0065-2598
Date Deposited: 04 Jan 2021 23:14
Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world and will soon become the number one cause of hepatocellular carcinoma (HCC), liver transplantation and liver-related mortality. The disease often occurs in the setting of metabolic conditions such as obesity and type II diabetes mellitus. These same metabolic drivers are also risk factors for NAFLD associated HCC which can occur even in the absence of cirrhosis or advanced fibrosis and appears to be phenotypically different to HCCs arising from other chronic liver diseases. The frequencies of liver-related events and HCC among NAFLD patients is low, especially when compared to cardiovascular disease and extrahepatic malignancies. However, the large denominator of total patients affected with NAFLD means that these events will impose an enormous clinical and economic burden on our society. Moreover, this burden is expected to rise further in the future. Therefore, the global NAFLD epidemic has arrived at our doorstep and demands our attention.

Creators:
Creators
Email
Liu, Ken
UNSPECIFIED
McCaughan, Geoffrey W.
UNSPECIFIED
Last Modified: 04 Jan 2021 23:14
URI: https://eprints.centenary.org.au/id/eprint/583

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