Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis

Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1155/2018%2F6053492
Journal or Publication Title: Oxidative Medicine and Cellular Longevity
Volume: 2018
Page Range: pp. 1-13
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1155/2018/6053492
ISSN: 1942-0900
Date Deposited: 03 Jan 2021 22:26
Abstract:

The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Sepsis is initiated by the host response to infection with organ damage, increased plasma free fatty acids, high levels of cortisol, massive cytokine production, leukocyte activation, and endothelial dysfunction. We aimed to analyze the effect of omega-9 supplementation on corticosteroid unbalance, inflammation, bacterial elimination, and peroxisome proliferator-activated receptor (PPAR) gamma expression, an omega-9 receptor and inflammatory modulator. We treated mice for 14 days with omega-9 and induced sepsis by cecal ligation and puncture (CLP). We measured systemic corticosterone levels, cytokine production, leukocyte and bacterial counts in the peritoneum, and the expression of PPAR gamma in both liver and adipose tissues during experimental sepsis. We further studied omega-9 effects on leukocyte rolling in mouse cremaster muscle-inflamed postcapillary venules and in the cerebral microcirculation of septic mice. Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-α and IL-1β in peritoneal lavage fluid of mice with sepsis. Omega-9 treatment also decreased systemic corticosterone levels. Neutrophil migration from circulation to the peritoneal cavity and leukocyte rolling on the endothelium were decreased by omega-9 treatment. Omega-9 also decreased bacterial load in the peritoneal lavage and restored liver and adipose tissue PPAR gamma expression in septic animals. Our data suggest a beneficial anti-inflammatory role of omega-9 in sepsis, mitigating leukocyte rolling and leukocyte influx, balancing cytokine production, and controlling bacterial growth possibly through a PPAR gamma expression-dependent mechanism. The significant reduction of inflammation detected after omega-9 enteral injection can further contribute to the already known beneficial properties facilitated by unsaturated fatty acid-enriched diets.

Creators:
Creators
Email
Medeiros-de-Moraes, Isabel Matos
UNSPECIFIED
Gonçalves-de-Albuquerque, Cassiano Felippe
UNSPECIFIED
Kurz, Angela R. M.
UNSPECIFIED
Oliveira, Flora Magno de Jesus
UNSPECIFIED
Abreu, Victor Hugo Pereira de
UNSPECIFIED
Torres, Rafael Carvalho
UNSPECIFIED
Carvalho, Vinícius Frias
UNSPECIFIED
Estato, Vanessa
UNSPECIFIED
Bozza, Patrícia Torres
UNSPECIFIED
Sperandio, Markus
UNSPECIFIED
Castro-Faria-Neto, Hugo Caire de
UNSPECIFIED
Silva, Adriana Ribeiro
UNSPECIFIED
Last Modified: 03 Jan 2021 22:26
URI: https://eprints.centenary.org.au/id/eprint/557

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