Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent

Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1071/CH18206
Journal or Publication Title: Australian Journal of Chemistry
Volume: 71
Number: 9
Page Range: p. 716
Date: 2018
Divisions: Tuberculosis
Depositing User: General Admin
Identification Number: 10.1071/CH18206
ISSN: 0004-9425
Date Deposited: 03 Jan 2021 22:38
Abstract:

Due to the prevalence of thioamides in antibacterial compounds, we chose to convert the amide in the antitubercular compound 2-(decylsulfonyl)acetamide to a thioamide using Lawesson’s reagent to study its activity against a range of microorganisms. This derivative (8) had significantly diminished activity against tuberculosis but slightly better activity than the parent compound against the Gram positive species Staphylococcus aureus. This activity against a second major pathogen is remarkable considering the structural simplicity of these compounds.

Creators:
Creators
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Sun, Hsien-Kuo
UNSPECIFIED
Pang, Angel
UNSPECIFIED
Farr, Dylan C.
UNSPECIFIED
Mosaiab, Tamim
UNSPECIFIED
Britton, Warwick J.
UNSPECIFIED
Anoopkumar-Dukie, Shailendra
UNSPECIFIED
Grice, I. Darren
UNSPECIFIED
Kiefel, Milton J.
UNSPECIFIED
West, Nick P.
UNSPECIFIED
Grant, Gary D.
UNSPECIFIED
Houston, Todd A.
UNSPECIFIED
Last Modified: 03 Jan 2021 22:38
URI: https://eprints.centenary.org.au/id/eprint/535

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