Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent.
Full text not available from this repository.Item Type: | Article |
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Status: | Published |
Official URL: | https://doi.org/10.1071/CH18206 |
Journal or Publication Title: | Australian Journal of Chemistry |
Volume: | 71 |
Number: | 9 |
Page Range: | p. 716 |
Date: | 2018 |
Divisions: | Tuberculosis |
Depositing User: | General Admin |
Identification Number: | 10.1071/CH18206 |
ISSN: | 0004-9425 |
Date Deposited: | 03 Jan 2021 22:38 |
Abstract: | Due to the prevalence of thioamides in antibacterial compounds, we chose to convert the amide in the antitubercular compound 2-(decylsulfonyl)acetamide to a thioamide using Lawesson’s reagent to study its activity against a range of microorganisms. This derivative (8) had significantly diminished activity against tuberculosis but slightly better activity than the parent compound against the Gram positive species Staphylococcus aureus. This activity against a second major pathogen is remarkable considering the structural simplicity of these compounds. |
Creators: | Creators Email Sun, Hsien-Kuo UNSPECIFIED Pang, Angel UNSPECIFIED Farr, Dylan C. UNSPECIFIED Mosaiab, Tamim UNSPECIFIED Britton, Warwick J. UNSPECIFIED Anoopkumar-Dukie, Shailendra UNSPECIFIED Grice, I. Darren UNSPECIFIED Kiefel, Milton J. UNSPECIFIED West, Nick P. UNSPECIFIED Grant, Gary D. UNSPECIFIED Houston, Todd A. UNSPECIFIED |
Last Modified: | 03 Jan 2021 22:38 |
URI: | https://eprints.centenary.org.au/id/eprint/535 |
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