Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling

Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1038/s41598-018-25874-y
Journal or Publication Title: Scientific Reports
Volume: 8
Number: 1
Date: 2018
Divisions: Diseases of the Aorta Lab
Depositing User: General Admin
Identification Number: 10.1038/s41598-018-25874-y
ISSN: 2045-2322
Date Deposited: 03 Jan 2021 22:44
Abstract:

Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary and peripheral arterial diseases. A major cause of pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation and migration. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects. However, its role in modulating VSMC neointima formation remains unexplored. Herein, we report that NGR1 inhibits serum-induced VSMC proliferation and migration by regulating VSMC actin cytoskeleton dynamics. Using a mouse femoral artery endothelium denudation model, we further demonstrate that systemic administration of NGR1 had a potent therapeutic effect in mice, significantly reducing neointimal hyperplasia following acute vessel injury. Mechanistically, we show that NGR1's mode of action is through inhibiting the activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling. Taken together, this study identified NGR1 as a potential therapeutic agent for combating restenosis after PTA in cardiovascular diseases.

Creators:
Creators
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Fang, Haihong
UNSPECIFIED
Yang, Shilin
UNSPECIFIED
Luo, Yingying
UNSPECIFIED
Zhang, Cheng
UNSPECIFIED
Rao, Yi
UNSPECIFIED
Liu, Renjing
UNSPECIFIED
Feng, Yulin
UNSPECIFIED
Yu, Jun
UNSPECIFIED
Last Modified: 03 Jan 2021 22:44
URI: https://eprints.centenary.org.au/id/eprint/528

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