Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer

Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.virol.2018.05.022
Journal or Publication Title: Virology
Volume: 521
Page Range: pp. 149-157
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1016/j.virol.2018.05.022
ISSN: 00426822
Date Deposited: 03 Jan 2021 22:52
Abstract:

Human papillomavirus (HPV), notably type 16, is a risk factor for up to 75% of oropharyngeal squamous cell carcinomas (SCC). It has been demonstrated that small non-coding RNAs known as microRNAs play a vital role in the cellular transformation process. In this study, we used an LNA array to further investigate the impact of HPV16 on the expression of microRNAs in oropharyngeal (tonsillar) cancer. A number of miRNAs were found to be deregulated, with miR-496 showing a four-fold decrease. Over-expression of the high risk E6 oncoprotein down-regulated miR-496, impacting upon the post-transcriptional control of the transcription factor E2F2. These HPV specific miRNAs were integrated with the HPV16 interactome to identify possible mechanistic pathways. These analyses provide insights into novel molecular interactions between HPV16 and miRNAs in oropharyngeal cancers.

Copyright © 2018. Published by Elsevier Inc.

Creators:
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Mason, Dayna
UNSPECIFIED
Zhang, Xiaoying
UNSPECIFIED
Marques, Tânia Monteiro
UNSPECIFIED
Rose, Barbara
UNSPECIFIED
Khoury, Samantha
UNSPECIFIED
Hill, Meredith
UNSPECIFIED
Deutsch, Fiona
UNSPECIFIED
Lyons, J. Guy
UNSPECIFIED
Gama-Carvalho, Margarida
UNSPECIFIED
Tran, Nham
UNSPECIFIED
Last Modified: 03 Jan 2021 22:52
URI: https://eprints.centenary.org.au/id/eprint/513

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