Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis

Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis.

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Item Type: Article
Status: Published
Official URL: https://doi.org/10.1016/j.jid.2018.06.168
Journal or Publication Title: Journal of Investigative Dermatology
Volume: 138
Number: 12
Page Range: pp. 2606-2616
Date: 2018
Divisions: Immune Imaging
Depositing User: General Admin
Identification Number: 10.1016/j.jid.2018.06.168
ISSN: 0022202X
Date Deposited: 03 Jan 2021 22:55

Atopic dermatitis (AD) is a highly debilitating disease with significant health impacts worldwide. It has been a difficult disease to treat because of the wide spectrum of clinical manifestations. Therefore, the current clinical management strategies are nonspecific. Previous studies have documented that AD disease progression is precipitated by a combination of skin barrier dysfunction, itch, and immune dysregulation. However, the precise roles played by effector cells and cytokines have not been fully elucidated. To address this, we established a prolonged model of AD, using MC903. The phenotype of this MC903 model closely resembles the one observed in AD patients, including inflammatory parameters, barrier dysfunction, itch, and histopathological characteristics, thereby providing a platform to evaluate targets for the treatment of AD. This model exposed cells and cytokines that are critically associated with disease severity, including eosinophils, TSLP, and IL-4/IL-13. Indeed, eosinophil depletion significantly ameliorated AD pathology, most notably barrier dysfunction, to a similar extent as blocking of the IL-4/IL-13 axis by genetic deletion of STAT6. Thus, this study has identified eosinophils to be critical for the development and maintenance of AD, thereby proposing these effector cells as therapeutic targets for the treatment of AD.

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Naidoo, Karmella
Jagot, Ferdinand
van den Elsen, Lieke
Pellefigues, Christophe
Jones, Angela
Luo, Huijun
Johnston, Karen
Painter, Gavin
Roediger, Ben
Lee, James
Weninger, Wolfgang
Le Gros, Graham
Forbes-Blom, Elizabeth
Last Modified: 03 Jan 2021 22:55
URI: https://eprints.centenary.org.au/id/eprint/506

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